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PUBLICATIONS
[IMMUNOSCORE] [Behind IMMUNOSCORE] [Related]


IMMUNOSCORE


The immune contexture in human tumours: impact on clinical outcome.
Fridman WH, Pages F, Sautes-Fridman C, Galon J.
Nat Rev Cancer. 2012 Mar 15;12(4):298-306. doi: 10.1038/nrc3245.
Abstract  | Article


The Immune Score as a New Possible Approach for the Classification of Cancer.
Galon J, Pages F, Marincola FM, Thurin M, Trinchieri G, Fox BA, Gajewski TF, Ascierto PA.
J Transl Med. 2012 Jan 3;10(1):1. [Epub ahead of print]
Abstract  | Article


Cancer immunology-analysis of host and tumor factors for personalized medicine.
Ogino S, Galon J, Fuchs CS, Dranoff G.
Nat Rev Clin Oncol. 2011 Aug 9. doi: 10.1038/nrclinonc.2011.122. [Epub ahead of print]
Abstract  | Article


Histopathological-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction.
Mlecnik B, Tosolini M, Kirilovsky A, Berger A, Bindea G, Meatchi T, Bruneval P, Trajanoski Z, Fridman W-H, Pages F, Galon J.
J Clin Oncol. 2011 Feb 20;29(6):610-8. Epub 2011 Jan 18.
Abstract  | Article


The in situ cytotoxic and memory T cells predict outcome in early-stage colorectal cancer patients
Pages F, Kirilovsky A, Mlecnik B, Tosolini M, Bindea G, Lagorce C, Wind P, Marliot F, Bruneval P, Zatloukal K, Trajanoski Z, Berger A, Fridman W-H, Galon J
J Clin Oncol 2009 Dec 10;27(35):5944-51. Epub 2009 Oct 26.
Abstract  | Article


The adaptive immunologic microenvironment in colorectal cancer: a novel perspective
Galon J, Fridman WH, Pages F
Cancer Res 2007. 67:1883-6
Abstract  | Article


Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce C, Tosolini M, Camus M, Berger A, Wind P, Zinzindohoue F, Bruneval P, Cugnenc P-H, Trajanoski Z, Fridman W-H, Pages F
Science 2006.313:1960-4
Abstract  | Article


Effector memory T cells, early metastasis, and survival in colorectal cancer
Pages F, Berger A, Camus M, Sanchez-Cabo F, Costes A, Molidor R, Mlecnik B, Kirilovsky A, Nilsson M, Damotte D, Meatchi T, Bruneval P, Cugnenenc PH, Trajanoski Z, Fridman WH, Galon J
N Engl J Med 2005.353:2654-66
Abstract  | Article




Publications behind IMMUNOSCORE


Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients.
Mlecnik B, Bindea G, Angell HK, Sasso MS, Obenauf AC, Fredriksen T, Lafontaine L, Bilocq AM, Kirilovsky A, Tosolini M, Waldner M, Berger A, Fridman WH, Rafii A, Valge-Archer V, Pages F, Speicher MR, Galon J.
Sci Transl Med. 2014 Mar 19;6(228):228ra37. doi: 10.1126/scitranslmed.3007240.
Abstract  | Article


Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.
Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, Angell H, Fredriksen T, Lafontaine L, Berger A, Bruneval P, Fridman WH, Becker C, Pages F, Speicher MR, Trajanoski Z, Galon J.
Immunity. 2013 Oct 17;39(4):782-95. doi: 10.1016/j.immuni.2013.10.003.
Abstract  | Article


Prognostic and Predictive Impact of Intra- and Peritumoral Immune Infiltrates.
Fridman WH, Galon J, Pages F, Tartour E, Sautes-Fridman C, Kroemer G.
Cancer Res. 2011 Sep 1;71(17):5601-5. Epub 2011 Aug 16. Review.
Abstract  | Article


The prognostic impact of anti-cancer immune response: a novel classification of cancer patients.
Bindea G, Mlecnik B, Fridman WH, Galon J.
Semin Immunopathol. 2011 Jul;33(4):335-40. Epub 2011 Apr 5.
Abstract  | Article


Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, Th2, Treg, Th17) in patients with colorectal cancer.
Tosolini M, Kirilovsky A, Mlecnik B, Fredriksen T, Mauger S, Bindea G, Berger A, Bruneval P, Fridman W, Pages F, Galon J.
Cancer Res. 2011 Feb 15;71(4):1263-71.
Abstract  | Article


Tumor immunosurveillance in human cancers.
Mlecnik B, Bindea G, Pages F, Galon J.
Cancer Metastasis Rev. 2011 Mar 8. 30(1):5-12.
Abstract  | Article


Immunosurveillance in human non-viral cancers.
Fridman WH, Mlecnik B, Bindea G, Pages F, Galon J
Current Opinion In Immunology 2011 Apr;23(2):272-8.
Abstract  | Article


Memory T-cell responses and survival in human cancer: remember to stay alive.
Camus M, Galon J.
Adv Exp Med Biol. 2010;684:166-77.
Abstract  | Article


Immune Infiltration in Human Cancer: Prognostic Significance and Disease Control
Fridman WH, Galon J, Dieu-Nosjean MC, Cremer I, Fisson S, Damotte D, Pages F, Tartour E, Sautes-Fridman C
Curr Top Microbiol Immunol 2011;344:1-24.
Abstract  | Article


Natural immunity to cancer in humans
Bindea G, Mlecnik B, Fridman WH, Pages F, Galon J
Current Opinion In Immunology 2010 Apr;22(2):215-22
Abstract  | Article


Biomolecular network reconstruction identifies T cell homing factors associated with survival in colorectal cancer
Mlecnik B, Tosolini M, Charoentong P, Kirilovsky A, Bindea G, Berger A, Camus M, Gillard M, Bruneval P, Fridman WH, Pages F, Trajanoski Z, Galon J
Gastroenterology 2010 Apr;138(4):1429-40. Epub 2009 Nov 10.
Abstract  | Article


Immune infiltration in human tumors: a prognostic factor that should not be ignored
Pages F, Galon J, Dieu-Nosjean M-C, Tartour E, Sautes-Fridman C, Fridman W-H
Oncogene 2010. 29: 1093-1102
Abstract  | Article


Coordination of intratumoral immune reaction and human colorectal cancer recurrence
Camus M, Tosolini M, Mlecnik B, Pagès F, Kirilovsky A, Berger A, Costes A, Bindea G, Charoentong P, Bruneval P, Trajanoski Z, Fridman W-H, Galon J
Cancer Res 2009. 69(6):2685-93
Abstract  | Article


Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure
Abouzahr S, Bismuth G, Gaudin C, Caroll O, Van Endert P, Jalil A, Dausset J, Vergnon I, Richon C, Kauffmann A, Galon J, Raposo G, Mami-Chouaib F, Chouaib S
Proc Natl Acad Sci U S A 2006.103:1428-33
Abstract  | Article


Epstein-Barr virus nuclear antigen 2 induces interleukin-18 receptor expression in B cells
Pages F, Galon J, Karaschuk G, Dudziak D, Camus M, Lazar V, Camilleri-Broet S, Lagorce-Pages C, Lebel-Binay S, Laux G, Fridman WH, Henglein B
Blood 2005.105:1632-9
Abstract  | Article


IL-18 is produced by prostate cancer cells and secreted in response to interferons
S Lebel-Binay, N Thiounn, G De Pinieux, A Vieillefond, B Debre, JY Bonnefoy, WH Fridman, F Pages
Int J Cancer 2003.106:827-35
Abstract  | Article


Adoptive immunotherapy for superficial bladder cancer with autologous macrophage activated killer cells
N Thiounn, F Pages, A Mejean, JL Descotes, WH Fridman, JL Romet-Lemonne
J Urol 2002.168:2373-6
Abstract  | Article


Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity
P Tang, TP Cheng, D Agnello, CY Wu, BD Hissong, WT Watford, HJ Ahn, J Galon, J Moss, M Vaughan, JJ O'Shea, M Gadina
Proc Natl Acad Sci U S A 2002.99:2625-9
Abstract  | Article


Local immunostimulation induced by intravesical administration of autologous interferon-gamma-activated macrophages in patients with superficial bladder cancer
F Pages, S Lebel-Binay, A Vieillefond, L Deneux, M Cambillau, O Soubrane, B Debre, D Tardy, JL Lemonne, JP Abastado, WH Fridman, N Thiounn
Clin Exp Immunol 2002.127:303-9
Abstract  | Article


Glucocorticoid-inducible genes that regulate T-cell function
PR Mittelstadt, J Galon, D Franchimont, JJ O'Shea, JD Ashwell
Ernst Schering Res Found Workshop 2002.:319-39
Abstract non disponible  | Article


Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
J Galon, D Franchimont, N Hiroi, G Frey, A Boettner, M Ehrhart-Bornstein, JJ O'Shea, GP Chrousos, SR Bornstein
Faseb J 2002.16:61-71
Abstract  | Article


Glucocorticoids and inflammation revisited: the state of the art. NIH clinical staff conference
D Franchimont, T Kino, J Galon, GU Meduri, G Chrousos
Neuroimmunomodulation 2002.10:247-60
Abstract  | Article


Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha
D Franchimont, J Galon, MS Vacchio, S Fan, R Visconti, DM Frucht, V Geenen, GP Chrousos, JD Ashwell, JJ O'Shea
J Immunol 2002.168:2212-8
Abstract  | Article


Modulation of tumor growth by inhibitory Fc(gamma) receptor expressed by human melanoma cells
L Cassard, JF Cohen-Solal, A Galinha, X Sastre-Garau, C Mathiot, J Galon, T Dorval, A Bernheim, WH Fridman, C Sautes-Fridman
J Clin Invest 2002.110:1549-57
Abstract  | Article


[Clinical relevance of interleukin-18 production in the intestinal mucosa]
F Zinzindohoue, F Pages, A Berger, C Danel, V Lazar, N Thiounn, WH Fridman, PH Cugnenc
Gastroenterol Clin Biol 2001.25:761-9
Abstract non disponible  | Article


Analysis of interleukin-18, interleukin-1 converting enzyme (ICE) and interleukin-18-related cytokines in Crohn's disease lesions
F Pages, V Lazar, A Berger, C Danel, S Lebel-Binay, F Zinzindohoue, P Desreumaux, C Cellier, N Thiounn, D Bellet, PH Cugnenc, WH Fridman
Eur Cytokine Netw 2001.12:97-104
Abstract  | Article


Differential gene expression profile of glucocorticoids, testosterone, and dehydroepiandrosterone in human cells
M Maurer, Z Trajanoski, G Frey, N Hiroi, J Galon, HS Willenberg, PW Gold, GP Chrousos, WA Scherbaum, SR Bornstein
Horm Metab Res 2001.33:691-5
Abstract  | Article


Soluble CD16 inhibits CR3 (CD11b/CD18)-mediated infection of monocytes/macrophages by opsonized primary R5 HIV-1
H Bouhlal, J Galon, MD Kazatchkine, WH Fridman, C Sautes-Fridman, N Haeffner Cavaillon
J Immunol 2001.166:3377-83
Abstract  | Article


The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers
I Aksentijevich, J Galon, M Soares, E Mansfield, K Hull, HH Oh, R Goldbach-Mansky, J Dean, B Athreya, AJ Reginato, M Henrickson, B Pons-Estel, JJ O'Shea, DL Kastner
Am J Hum Genet 2001.69:301-14
Abstract  | Article


Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation
YJ Zhou, KS Magnuson, TP Cheng, M Gadina, DM Frucht, J Galon, F Candotti, RL Geahlen, PS Changelian, JJ O'Shea
Mol Cell Biol 2000.20:4371-80
Abstract  | Article


Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract
F Pages, A Berger, S Lebel-Binay, F Zinzindohoue, C Danel, B Piqueras, O Carriere, N Thiounn, PH Cugnenc, WH Fridman
Immunol Lett 2000.75:9-14
Abstract  | Article


Interleukin-18: biological properties and clinical implications
S Lebel-Binay, A Berger, F Zinzindohoue, P Cugnenc, N Thiounn, WH Fridman, F Pages
Eur Cytokine Netw 2000.11:15-26
Abstract  | Article


TNFRSF1A mutations and autoinflammatory syndromes
J Galon, I Aksentijevich, MF McDermott, JJ O'Shea, DL Kastner
Curr Opin Immunol 2000.12:479-86
Abstract  | Article


Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation
DM Frucht, M Aringer, J Galon, C Danning, M Brown, S Fan, M Centola, CY Wu, N Yamada, H El Gabalawy, JJ O'Shea
J Immunol 2000.164:4659-64
Abstract  | Article


Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes
D Franchimont, J Galon, M Gadina, R Visconti, Y Zhou, M Aringer, DM Frucht, GP Chrousos, JJ O'Shea
J Immunol 2000.164:1768-74
Abstract  | Article


Adrenal cortical activation in murine colitis
D Franchimont, G Bouma, J Galon, GW Wolkersdorfer, A Haidan, GP Chrousos, SR Bornstein
Gastroenterology 2000.119:1560-8
Abstract  | Article


The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators
M Centola, G Wood, DM Frucht, J Galon, M Aringer, C Farrell, DW Kingma, ME Horwitz, E Mansfield, SM Holland, JJ O'Shea, HF Rosenberg, HL Malech, DL Kastner
Blood 2000.95:3223-31
Abstract  | Article


Do glucocorticoids participate in thymocyte development?
JD Ashwell, MS Vacchio, J Galon
Immunol Today 2000.21:644-6
Abstract non disponible  | Article


TGF-beta does not inhibit IL-12- and IL-2-induced activation of Janus kinases and STATs
C Sudarshan, J Galon, Y Zhou, JJ O'Shea
J Immunol 1999.162:2974-81
Abstract  | Article


Control of tumor development by intratumoral cytokines
F Pages, V Vives, C Sautes-Fridman, F Fossiez, A Berger, PH Cugnenc, E Tartour, WH Fridman
Immunol Lett 1999.68:135-9
Abstract  | Article


Modulation of interleukin-18 expression in human colon carcinoma: consequences for tumor immune surveillance
F Pages, A Berger, B Henglein, B Piqueras, C Danel, F Zinzindohoue, N Thiounn, PH Cugnenc, WH Fridman
Int J Cancer 1999.84:326-30
Abstract  | Article


Regulation of production of soluble Fc gamma receptors type III in normal and pathological conditions
I Moldovan, J Galon, I Maridonneau-Parini, S Roman Roman, C Mathiot, WH Fridman, C Sautes-Fridman
Immunol Lett 1999.68:125-34
Abstract  | Article


Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes
MF McDermott,I Aksentijevich, J Galon, EM McDermott, BW Ogunkolade, M Centola, E Mansfield, M Gadina, L Karenko, T Pettersson, J McCarthy, DM Frucht, M Aringer, Y Torosyan, AM Teppo, M Wilson, HM Karaarslan
Cell 1999.97:133-44
Abstract  | Article


Soluble CD16 in plasma cell dyscrasias
C Mathiot, J Galon, E Tartour, JL Teillaud, T Facon, R Bataille, WH Fridman, C Sautes
Leuk Lymphoma 1999.32:467-74
Abstract  | Article


Presentation of antigen in immune complexes is boosted by soluble bacterial immunoglobulin binding proteins
M Leonetti, J Galon, R Thai, C Sautes-Fridman, G Moine, A Menez
J Exp Med 1999.189:1217-28
Abstract  | Article


IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells
J Galon, C Sudarshan, S Ito, D Finbloom, JJ O'Shea
J Immunol 1999.162:7256-62
Abstract  | Article


Prognostic and Predictive Impact of Intra- and Peritumoral Immune Infiltrates.
Fridman WH, Galon J, Pages F, Tartour E, Sautes-Fridman C, Kroemer G.
Cancer Res. 2011 Sep 1;71(17):5601-5. Epub 2011 Aug 16. Review.
Abstract  | Article


Cancer immunology-analysis of host and tumor factors for personalized medicine.
Ogino S, Galon J, Fuchs CS, Dranoff G.
Nat Rev Clin Oncol. 2011 Aug 9. doi: 10.1038/nrclinonc.2011.122. [Epub ahead of print]
Abstract  | Article


The prognostic impact of anti-cancer immune response: a novel classification of cancer patients.
Bindea G, Mlecnik B, Fridman WH, Galon J.
Semin Immunopathol. 2011 Jul;33(4):335-40. Epub 2011 Apr 5.
Abstract  | Article


Future Perspectives in melanoma research: Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6th-7th 2010".
Ascierto PA, De Maio E, Bertuzzi S, Palmieri G, Halaban R, Hendrix M, Kashani-Sabet M, Ferrone S, Wang E, Cochran A, Rivoltini L, Lee PP, Fox B, Kirkwood JM, Dansky-Ullmann C, Lehmann FF, Sznol M, Schwartzentruber DJ, Maio M, Flaherty K, Galon J, Ribas A, Yang J, Stroncek DF, Mozzillo N, Marincola FM.
J Transl Med. 2011 Mar 26;9:32.
Abstract  | Article


Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, Th2, Treg, Th17) in patients with colorectal cancer.
Tosolini M, Kirilovsky A, Mlecnik B, Fredriksen T, Mauger S, Bindea G, Berger A, Bruneval P, Fridman W, Pages F, Galon J.
Cancer Res. 2011 Feb 15;71(4):1263-71.
Abstract  | Article


hSMG-1 is a granzyme B-associated stress-responsive protein kinase.
Meslin F, Hamai A, Mlecnik B, Rosselli F, Richon C, Jalil A, Wemhoff G, Thiery J, Galon J, Chouaib S.
J Mol Med. 2011 Apr;89(4):411-21.
Abstract  | Article


Tumor immunosurveillance in human cancers.
Mlecnik B, Bindea G, Pages F, Galon J.
Cancer Metastasis Rev. 2011 Mar 8. 30(1):5-12.
Abstract  | Article


Immunosurveillance in human non-viral cancers.
Fridman WH, Mlecnik B, Bindea G, Pages F, Galon J
Current Opinion In Immunology 2011 Apr;23(2):272-8.
Abstract  | Article


Information technology solutions for integration of biomolecular and clinical data in the identification of new cancer biomarkers and targets for therapy.
Hackl H, Stocker G, Charoentong P, Mlecnik B, Bindea G, Galon J, Trajanoski Z.
Pharmacol Ther 2010 Dec 128(3):488-98. Epub 2010 Sep 9.
Abstract  | Article


Memory T-cell responses and survival in human cancer: remember to stay alive.
Camus M, Galon J.
Adv Exp Med Biol. 2010;684:166-77.
Abstract  | Article


Immune Infiltration in Human Cancer: Prognostic Significance and Disease Control
Fridman WH, Galon J, Dieu-Nosjean MC, Cremer I, Fisson S, Damotte D, Pages F, Tartour E, Sautes-Fridman C
Curr Top Microbiol Immunol 2011;344:1-24.
Abstract  | Article


Natural immunity to cancer in humans
Bindea G, Mlecnik B, Fridman WH, Pages F, Galon J
Current Opinion In Immunology 2010 Apr;22(2):215-22
Abstract  | Article


Data integration and exploration for the identification of molecular mechanisms in tumor-immune cells interaction
Mlecnik B, Sanchez-Cabo F, Charoentong P, Bindea G, Pages F, Berger A, Galon J, Trajanoski Z
BMC Genomics 2010;11 Suppl 1:S7.
Abstract  | Article


Biomolecular network reconstruction identifies T cell homing factors associated with survival in colorectal cancer
Mlecnik B, Tosolini M, Charoentong P, Kirilovsky A, Bindea G, Berger A, Camus M, Gillard M, Bruneval P, Fridman WH, Pages F, Trajanoski Z, Galon J
Gastroenterology 2010 Apr;138(4):1429-40. Epub 2009 Nov 10.
Abstract  | Article


iLAP: a workflow-driven software for experimental protocol development, data acquisition and analysis
Stocker G, Fischer M, Rieder D, Bindea G, Kainz S, Oberstolz M, McNally JG, Trajanoski Z
BMC Bioinformatics 2009. 10(1):390
Abstract  | Article


Immune infiltration in human tumors: a prognostic factor that should not be ignored
Pages F, Galon J, Dieu-Nosjean M-C, Tartour E, Sautes-Fridman C, Fridman W-H
Oncogene 2010. 29: 1093-1102
Abstract  | Article


ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks
Bindea G*, Mlecnik B*, Hackl H, Charoentong P, Tosolini M, Kirilovsky A, Fridman W-H, Pages F, Trajanoski Z, Galon J
Bioinformatics 2009. 25(8):1091-1093
Abstract  | Article


Coordination of intratumoral immune reaction and human colorectal cancer recurrence
Camus M, Tosolini M, Mlecnik B, Pagès F, Kirilovsky A, Berger A, Costes A, Bindea G, Charoentong P, Bruneval P, Trajanoski Z, Fridman W-H, Galon J
Cancer Res 2009. 69(6):2685-93
Abstract  | Article


A new platform linking chromosomal and sequence information
Kowalska A, Bozsaky E, Ramsauer T, Rieder D, Bindea G, Lorch T, Trajanoski Z, Ambros PF
Chromosome Res 2007. 15:327-340
Abstract  | Article


LPL-mediated lipolysis of VLDL induces an upregulation of AU-rich mRNAs and an activation of HuR in endothelial cells
Tschernatsch MMO, Mlecnik B, Trajanoski Z, Zechner R, Zimmermann R
Atherosclerosis 2006 Dec;189(2):310-7. Epub 2006 Feb 21.
Abstract  | Article


Identification of target actin content and polymerization status as a mechanism of tumor resistance after cytolytic T lymphocyte pressure
Abouzahr S, Bismuth G, Gaudin C, Caroll O, Van Endert P, Jalil A, Dausset J, Vergnon I, Richon C, Kauffmann A, Galon J, Raposo G, Mami-Chouaib F, Chouaib S
Proc Natl Acad Sci U S A 2006.103:1428-33
Abstract  | Article


PathwayExplorer: web service for visualizing high-throughput expression data on biological pathways
Mlecnik B, Scheideler M, Hackl H, Hartler J, Sanchez-Cabo F , Trajanoski Z
Nucleic Acids Res 2005. 33: W633-W637
Abstract  | Article


Epstein-Barr virus nuclear antigen 2 induces interleukin-18 receptor expression in B cells
Pages F, Galon J, Karaschuk G, Dudziak D, Camus M, Lazar V, Camilleri-Broet S, Lagorce-Pages C, Lebel-Binay S, Laux G, Fridman WH, Henglein B
Blood 2005.105:1632-9
Abstract  | Article


GOLD.db: Genomics of lipid-asociated disorders database
Hackl H, Maurer M, Mlecnik B, Hartler J, Stocker G, Miranda-Saavedra D, Trajanoski Z
BMC Genomics 2004.5:93
Abstract  | Article


Client-Server Environment for High-Performance Gene Expression Data Analysis
Sturn A, Mlecnik B, Pieler R, Rainer J, Truskaller T, Trajanoski Z
Bioinformatics 2003. 19:772-773
Abstract  | Article


IL-18 is produced by prostate cancer cells and secreted in response to interferons
S Lebel-Binay, N Thiounn, G De Pinieux, A Vieillefond, B Debre, JY Bonnefoy, WH Fridman, F Pages
Int J Cancer 2003.106:827-35
Abstract  | Article


Adoptive immunotherapy for superficial bladder cancer with autologous macrophage activated killer cells
N Thiounn, F Pages, A Mejean, JL Descotes, WH Fridman, JL Romet-Lemonne
J Urol 2002.168:2373-6
Abstract  | Article


Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity
P Tang, TP Cheng, D Agnello, CY Wu, BD Hissong, WT Watford, HJ Ahn, J Galon, J Moss, M Vaughan, JJ O'Shea, M Gadina
Proc Natl Acad Sci U S A 2002.99:2625-9
Abstract  | Article


Local immunostimulation induced by intravesical administration of autologous interferon-gamma-activated macrophages in patients with superficial bladder cancer
F Pages, S Lebel-Binay, A Vieillefond, L Deneux, M Cambillau, O Soubrane, B Debre, D Tardy, JL Lemonne, JP Abastado, WH Fridman, N Thiounn
Clin Exp Immunol 2002.127:303-9
Abstract  | Article


Glucocorticoid-inducible genes that regulate T-cell function
PR Mittelstadt, J Galon, D Franchimont, JJ O'Shea, JD Ashwell
Ernst Schering Res Found Workshop 2002.:319-39
Abstract non disponible  | Article


Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
J Galon, D Franchimont, N Hiroi, G Frey, A Boettner, M Ehrhart-Bornstein, JJ O'Shea, GP Chrousos, SR Bornstein
Faseb J 2002.16:61-71
Abstract  | Article


Glucocorticoids and inflammation revisited: the state of the art. NIH clinical staff conference
D Franchimont, T Kino, J Galon, GU Meduri, G Chrousos
Neuroimmunomodulation 2002.10:247-60
Abstract  | Article


Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha
D Franchimont, J Galon, MS Vacchio, S Fan, R Visconti, DM Frucht, V Geenen, GP Chrousos, JD Ashwell, JJ O'Shea
J Immunol 2002.168:2212-8
Abstract  | Article


Modulation of tumor growth by inhibitory Fc(gamma) receptor expressed by human melanoma cells
L Cassard, JF Cohen-Solal, A Galinha, X Sastre-Garau, C Mathiot, J Galon, T Dorval, A Bernheim, WH Fridman, C Sautes-Fridman
J Clin Invest 2002.110:1549-57
Abstract  | Article


[Clinical relevance of interleukin-18 production in the intestinal mucosa]
F Zinzindohoue, F Pages, A Berger, C Danel, V Lazar, N Thiounn, WH Fridman, PH Cugnenc
Gastroenterol Clin Biol 2001.25:761-9
Abstract non disponible  | Article


Analysis of interleukin-18, interleukin-1 converting enzyme (ICE) and interleukin-18-related cytokines in Crohn's disease lesions
F Pages, V Lazar, A Berger, C Danel, S Lebel-Binay, F Zinzindohoue, P Desreumaux, C Cellier, N Thiounn, D Bellet, PH Cugnenc, WH Fridman
Eur Cytokine Netw 2001.12:97-104
Abstract  | Article


Differential gene expression profile of glucocorticoids, testosterone, and dehydroepiandrosterone in human cells
M Maurer, Z Trajanoski, G Frey, N Hiroi, J Galon, HS Willenberg, PW Gold, GP Chrousos, WA Scherbaum, SR Bornstein
Horm Metab Res 2001.33:691-5
Abstract  | Article


Soluble CD16 inhibits CR3 (CD11b/CD18)-mediated infection of monocytes/macrophages by opsonized primary R5 HIV-1
H Bouhlal, J Galon, MD Kazatchkine, WH Fridman, C Sautes-Fridman, N Haeffner Cavaillon
J Immunol 2001.166:3377-83
Abstract  | Article


The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers
I Aksentijevich, J Galon, M Soares, E Mansfield, K Hull, HH Oh, R Goldbach-Mansky, J Dean, B Athreya, AJ Reginato, M Henrickson, B Pons-Estel, JJ O'Shea, DL Kastner
Am J Hum Genet 2001.69:301-14
Abstract  | Article


Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation
YJ Zhou, KS Magnuson, TP Cheng, M Gadina, DM Frucht, J Galon, F Candotti, RL Geahlen, PS Changelian, JJ O'Shea
Mol Cell Biol 2000.20:4371-80
Abstract  | Article


Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract
F Pages, A Berger, S Lebel-Binay, F Zinzindohoue, C Danel, B Piqueras, O Carriere, N Thiounn, PH Cugnenc, WH Fridman
Immunol Lett 2000.75:9-14
Abstract  | Article


Interleukin-18: biological properties and clinical implications
S Lebel-Binay, A Berger, F Zinzindohoue, P Cugnenc, N Thiounn, WH Fridman, F Pages
Eur Cytokine Netw 2000.11:15-26
Abstract  | Article


TNFRSF1A mutations and autoinflammatory syndromes
J Galon, I Aksentijevich, MF McDermott, JJ O'Shea, DL Kastner
Curr Opin Immunol 2000.12:479-86
Abstract  | Article


Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation
DM Frucht, M Aringer, J Galon, C Danning, M Brown, S Fan, M Centola, CY Wu, N Yamada, H El Gabalawy, JJ O'Shea
J Immunol 2000.164:4659-64
Abstract  | Article


Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes
D Franchimont, J Galon, M Gadina, R Visconti, Y Zhou, M Aringer, DM Frucht, GP Chrousos, JJ O'Shea
J Immunol 2000.164:1768-74
Abstract  | Article


Adrenal cortical activation in murine colitis
D Franchimont, G Bouma, J Galon, GW Wolkersdorfer, A Haidan, GP Chrousos, SR Bornstein
Gastroenterology 2000.119:1560-8
Abstract  | Article


The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators
M Centola, G Wood, DM Frucht, J Galon, M Aringer, C Farrell, DW Kingma, ME Horwitz, E Mansfield, SM Holland, JJ O'Shea, HF Rosenberg, HL Malech, DL Kastner
Blood 2000.95:3223-31
Abstract  | Article


Do glucocorticoids participate in thymocyte development?
JD Ashwell, MS Vacchio, J Galon
Immunol Today 2000.21:644-6
Abstract non disponible  | Article


TGF-beta does not inhibit IL-12- and IL-2-induced activation of Janus kinases and STATs
C Sudarshan, J Galon, Y Zhou, JJ O'Shea
J Immunol 1999.162:2974-81
Abstract  | Article


Control of tumor development by intratumoral cytokines
F Pages, V Vives, C Sautes-Fridman, F Fossiez, A Berger, PH Cugnenc, E Tartour, WH Fridman
Immunol Lett 1999.68:135-9
Abstract  | Article


Modulation of interleukin-18 expression in human colon carcinoma: consequences for tumor immune surveillance
F Pages, A Berger, B Henglein, B Piqueras, C Danel, F Zinzindohoue, N Thiounn, PH Cugnenc, WH Fridman
Int J Cancer 1999.84:326-30
Abstract  | Article


Regulation of production of soluble Fc gamma receptors type III in normal and pathological conditions
I Moldovan, J Galon, I Maridonneau-Parini, S Roman Roman, C Mathiot, WH Fridman, C Sautes-Fridman
Immunol Lett 1999.68:125-34
Abstract  | Article


Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes
MF McDermott,I Aksentijevich, J Galon, EM McDermott, BW Ogunkolade, M Centola, E Mansfield, M Gadina, L Karenko, T Pettersson, J McCarthy, DM Frucht, M Aringer, Y Torosyan, AM Teppo, M Wilson, HM Karaarslan
Cell 1999.97:133-44
Abstract  | Article


Soluble CD16 in plasma cell dyscrasias
C Mathiot, J Galon, E Tartour, JL Teillaud, T Facon, R Bataille, WH Fridman, C Sautes
Leuk Lymphoma 1999.32:467-74
Abstract  | Article


Presentation of antigen in immune complexes is boosted by soluble bacterial immunoglobulin binding proteins
M Leonetti, J Galon, R Thai, C Sautes-Fridman, G Moine, A Menez
J Exp Med 1999.189:1217-28
Abstract  | Article


IL-12 induces IFN regulating factor-1 (IRF-1) gene expression in human NK and T cells
J Galon, C Sudarshan, S Ito, D Finbloom, JJ O'Shea
J Immunol 1999.162:7256-62
Abstract  | Article




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